[CS] Today! Mar. 5 ASSISTANT PROFESSOR of STATISTICS *CANDIDATE JOB TALK* Wednesday, March 5 at 4:00 in the ASH Auditorium

[Paula Harmon]

Gregory J. Matthews, Post-Doctoral Research Fellow and Lecturer in the 
Division of Biostatistics and Epidemiology, UMass, Amherst

"Genome Wide Association Studies (GWAS) and Mixed Modeling of 
Meta-Analysis P-values (MixMAP)"
Wednesday, March 5 at 4:00 p.m., in ASH Auditorium

Abstract: With advances in technology, mapping of the human genome has 
become easier and cheaper than ever before.  This has led to an increase 
in studies searching for associations between genetic variation and 
complex diseases.  These studies are conducted by scanning across the 
genome at locations of genetic variability called single nucleotide 
polymorphisms (SNPs) seeking to detect associations with complex disease 
phenotypes.  These studies are referred to as genome wide association 
studies (GWAS).  Whereas in a GWAS large parts of the genome are 
scanned, candidate gene studies target a specific set of genes for 
exploration based on previous biological information and are then 
analyzed similarly to GWAS. Results of a candidate gene study performed 
to find genetic loci that are associated with coronary artery 
calcification (CAC) in patients with chronic kidney disease (CKD) will 
be presented.  Along with this analysis, a proposed methodology, termed 
MixMAP, for identifying gene-level, as opposed to SNP level, 
associations will be described.  Finally, results of applications of 
MixMAP to two large meta-analyses will be presented as well as a brief 
example of the software that we have developed.

Biography: Gregory J. Matthews received his Ph. D. in statistics from 
the University of Connecticut in 2011 and has spent the past three years 
as a post-doctoral research fellow and lecturer at the University of 
Massachusetts in the Division of Biostatistics and Epidemiology. Prior 
to this, he attended Worcester Polytechnic Institute (WPI) as both an 
undergraduate, where he graduated with distinction, and for a master's 
degree in applied statistics. His current research interests include 
analysis of high dimensional genetic data, statistical disclosure 
control, and the analysis of sports. He actively writes about statistics 
for a more general audience and his work has appeared on many websites 
including the ASA's Significance blog, TeamRankings.com, and Deadspin as 
well as his own blog StatsInTheWild.com.

test two
Paula Harmon, Administrative Assistant
School of Cognitive Science
Hampshire College
893 West Street Amherst, MA 01002
phone: 413.559.5502
fax: 413.559.5438
http://cs.hampshire.edu <http://cs.hampshire.edu/>
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